Restoring Vitality through Personalized Hormone Therapy

THE ADRENAL GLAND
Falling asleep at your desk? Feeling Tired but Wired? Perhaps its time to check your Adrenals…

ADRENAL FATIGUE
The adrenal glands are responsible for the secretion of stress hormones, such as cortisol, epinephrine and norepinephrine. The adrenals are also responsible for secreting DHEA, an important precursor to sex hormones and potent “anti-aging” hormone.

ADRENAL DYSFUNCTION
Adrenal dysfunction (also know as “adrenal fatigue”) occurs when the adrenal glands over- or under-function. This syndrome can often manifest as weight gain, burn out and poor energy, stress intolerance, brain fog, poor immunity, anxiety and depression, poor blood sugar management, food cravings and low libido.
Adrenal dysfunction can also affect the balance of other hormone systems in your body, such as reproductive and thyroid hormones.

ADRENAL GLAND BASICS, CORTISOL & ESTROGEN DOMINANCE
The adrenal glands are two small glands about the size of a large grape and are situated on top of the kidneys. The adrenal glands help the body cope with stress.

The adrenal glands have 2 compartments:
Medulla or inner portion – modulate the sympathetic nervous system (fight or flight) through secretion of two hormones called epinephrine and nor epinephrine
Outer adrenal cortex – comprises 80% of the adrenal gland and is responsible for producing over 50 different types of hormones in three major classes – glucocorticoids, mineralcorticoids and androgens.

The most important glucocorticoid is cortisol. When this is lowered, the body will be less effective in dealing with stress.

The adrenal cortex is responsible for producing all sex hormones, although in small amounts. However, there is one hormone called DHEA that is made in large amounts in both sexes.

CORTISOL
The most important anti-stress hormone in the body is cortisol. Cortisol protects the body from excessive stress by:

Normalizing Blood Sugar – cortisol increases blood sugar levels in the body, thus providing the energy for the body to physically escape the threat. Cortisol works with insulin from the pancreas to provide adequate glucose to the cells for energy. In adrenal fatigue, more cortisol is secreted in the early stages. In later stages (when the adrenal glands become exhausted), cortisol output is reduced, and blood sugar balance becomes a problem.

Anti-Inflammatory Response – cortisol is a powerful anti-inflammatory agent. Its objective is to remove and prevent swelling and redness of nearly all tissues. These anti-inflammatory responses prevent mosquito bites from enlarging, bronchial tubes and eyes from swelling shut from allergies, and swelling from becoming too intense.

Immune System Suppression – people with high cortisol levels are much weaker from the immunological point of view. Cortisol suppresses white blood cells, natural killer cells, monocytes, macrophages and mast cells. It also suppresses the autoimmune system response to foreign insult.

Vasoconstriction – Cortisol contracts mid-size arteries. People with low cortisol (as in advance stages of adrenal fatigue) have low blood pressure. Cortisol tends to increase blood pressure.

Physiology of Stress – people with adrenal fatigue cannot tolerate stress and will then succumb to severe stress. As their stress increases, progressively higher levels of cortisol are required. When the cortisol level cannot rise in response to stress, it is impossible to maintain the body in optimum stress response.
COMMON CAUSES OF ADRENAL FATIGUE

Chronic stress is very common in western society. The most common cause of stress are work pressures, death of a love one, moving house, changing jobs, illness and marital disruptions. Adrenal fatigue occurs when the amount of stress overextends the capacity of the body to compensate and recover from stress.

Stressors that can lead to adrenal fatigue include:

  • Anger
  • Chronic fatigue
  • Chronic illness
  • Chronic pain
  • Depression
  • Excessive exercise
  • Fear and guilt
  • Gluten intolerance
  • Low blood sugar
  • Chronic or severe infection
  • Malabsorption
  • Excessive sugar in the diet
  • Excessive caffeine intake
  • Toxic exposure
  • Severe or chronic stress
  • Surgery
  • Late hours
  • Sleep deprivation

HOW STRESSORS AFFECT THE BODY
When a person is stressed, the body reacts by mounting a stress response – fight or flight! When a person experiences chronic stress, the cortisol levels may rise to such a high level that its production reduces as the adrenals become exhausted.

When cortisol is at extremely high levels another hormone called DHEA, starts to drop. The result is a high cortisol to DHEA ratio resulting in:

Reduced insulin sensitivity, reduced glucose utilization and increased blood sugar (can lead to weight gain and diabetes) Increased chances of getting infections such as Herpes, yeast overgrowth, and viral infections Increased loss in bone mass as calcium absorption is blocked and demineralization of bone occurs – leading to osteoporosis Increased fat accumulation around the waist and protein breakdown, leading to muscle wasting and an inability to reduce weight Increased water and salt retention leading to high blood pressure Estrogen dominance, leading to PMS, uterine fibroids, and breast cancer

ADRENAL FATIGUE PROGRESSION

As the adrenals are constantly being signaled to produce more epinephrine, cortisol output is increasing in response. After some time, the adrenals will experience difficulties in meeting the body’s increasing demand for cortisol. The adrenals which make other hormones such as pregnenolone, DHEA, testosterone and estrogen, are too busy trying to make cortisol and the production of these other hormones decline.

Usually over a few years of constant stress, the cortisol production is reduced as the adrenals are too exhausted. Severe sex hormone imbalances (estrogen, progesterone, and testosterone) occur at this point.

The adrenal glands are responsible for producing about 35% of female hormones premenopausal and about 50% in menopause. Today, women often have exhausted adrenal glands by the time they reach their mid-thirties or early forties due to a stressful lifestyle.

ESTROGEN DOMINANCE

When too much cortisol is being produced, it will have multiple undesirable effects. For example, cortisol blocks progesterone receptors, making them less responsive to progesterone. Progesterone normally produced by the adrenal glands comes to a halt in favour of cortisol. Insufficient progesterone production leads to an imbalance of estrogen to progesterone. With reduced progesterone to offset estrogen, the body may experience undesirable effects. It is no coincidence that we see a proliferation of conditions associated with excessive estrogen (see estrogen dominance symptoms on website). Balancing hormones is much easier once adrenal function is improved.

Symptoms of adrenal fatigue are not always clear and can often be confused with many other problems. But by far the most common symptom is exertional fatigue. People often say, “I’m tired, I’m weak, I don’t have the energy I used to have, or I have to nap in the afternoon”.
There are other symptoms of adrenal fatigue:
  • Weakness after not eating for a while
  • Dizziness
  • Headaches of different kinds
  • Trouble thinking clearly
  • Dizziness when you get up too quickly
  • Low blood pressure (more common in women)
  • Heart palpitations (irregular heart beat)
  • Trouble getting out of bed in the morning
  • Tender spots in muscles, particularly the neck and lower back
  • Generalized aches and pains
  • Cravings for sugar, carbohydrates, and/or coffee
  • Weight gain in the waist
  • Nervousness / Anxiety
  • Cold extremities
  • Vertical nail ridges
TESTING:
There are several ways to test your adrenal hormones. One of the best ways to test your stress hormone production throughout the day is to do a four-point salivary cortisol test. While a blood cortisol test will only test cortisol levels at one point in time, this test gives you a picture of your cortisol secretion throughout the day so that you can see if it follows a normal curve or not.

TREATMENT:
Naturopathic treatment for adrenal dysfunction can involve diet and lifestyle modification, stress management strategies, supplementation, IV therapy and /or botanical medicine.

THE THYROID GLAND
The Thyroid gland is responsible for secreting the thyroid hormones, T3 and T4. These hormones set the body’s internal thermometer and determine the rate of metabolism.

HYPOTHYROID
If the thyroid is unable to secrete enough thyroid hormones, hypothyroidism occurs. This means that the body’s set metabolic rate will decrease and symptoms such as weight gain, hair loss, fatigue, constipation, dry skin, depression, cold intolerance, irregular or heavy menses, low libido, elevated cholesterol and poor memory may occur.

An imbalance of other hormones, such as Estrogen or stress hormones may negatively affect thyroid function.

An autoimmune condition called Hashimoto’s disease is a very common cause of hypothyroidism that is often overlooked in the conventional medical system. Hashimoto’s may be related to inflammation from food allergies and dysbiosis, or environmental toxins.

Many patients also present with subclinical hypothyroidism, where they experience the signs and symptoms hypothyroidism, but their blood thyroid hormone levels are normal.

HYPERTHYROID
Hyperthyroidism occurs when the thyroid secretes an excess of thyroid hormones. Symptoms include an increased heart rate, weight loss, excessive sweating, anxiety and agitation, fatigue, tremor and increased bowel movements. The most common cause of hyperthyroidism is an autoimmune condition called Graves Disease.

TESTING:
We offer a full thyroid hormone panel at Hormone by Design, which tests for TSH (Thyroid stimulating hormone), T3, T4 and Anti-TPO antibodies (present in auto-immune hypothyroidism or Hashimoto’s). In the conventional system, T3 and T4 will not be tested if TSH levels are normal but many people will have abnormal T3 and T4 levels despite normal blood levels of TSH.

TREATMENT:
Naturopathic treatment for thyroid disorders depends on the severity of the symptoms and can include dietary and lifestyle modifications, nutritional supplementation, botanical medicine or thyroid hormone replacement.

HORMONE RESTORATION FOR MENOPAUSE


Menopause signs, symptoms and stages
Most women enter menopause without understanding what is happening to them or why they’re experiencing so many symptoms. Your mother just toughed out the hot flashes and night sweats, so why can’t you? Your doctor says your symptoms are normal, but if it’s just menopause, why do all these symptoms start in your mid to late 40s or early 50’s and last for 20 years? Are women meant to suffer these symptoms forever and not lead a full and active life as they are meant to?

Let’s end the confusion with some real information on how to deal with this phase of life.

Table Of Contents
  • 1. What is menopause?
  • 2. Stages of menopause: what is the difference between menopause, perimenopause and postmenopause?
  • 3. Symptoms and causes of menopause
  • 4. How will I know I’m in menopause?
  • 5. Treatments for perimenopause and menopause
What is menopause?
Menopause is a time of natural transition in a woman’s life that results in the end of a her monthly periods and reproductive cycles.

In many ways, menopause is the bookend of puberty. As you entered your teen years decades ago, sex hormone production ramped up, bringing on menstruation and fertility. In menopause, the reverse process happens as sex hormone production, including estrogen and progesterone, downshifts to post-reproductive levels.

If you recall from your teen years, hormonal shifts and fluctuations can be miserable at times, and the same is true during menopause. Women in menopause are susceptible to developing intense hormonal imbalances that trigger the uncomfortable symptoms we’ve come to associate with the menopause transition: hot flashes, night sweats, anxiety, low libido, irritability and more.
Starting your period was simply a natural part of your lifecycle as a women — and stopping your monthly period is too.

Understanding menopause (correctly) as the natural process it is for all women doesn’t mean that your menopause symptoms are not real or should be diminished. Menopause is inevitable for every woman, but struggling through intense menopause symptoms is not. If you are experiencing symptoms, it’s a clear signal that your hormones need support during this transition. Hormones can either have a gentle down glide through menopause or they can hit turbulence and wreak havoc on your life.

Restoring and balancing your hormones at this very important stage of your life is critical if you choose to decide you want to enjoy life to its fullest. There’s a lot of science behind this approach. Menopause is a time of change, but it’s completely possible to make it through this transition feeling stronger, vibrant and in control of your health.

Stages of menopause: what is the difference between menopause, perimenopause and post-menopause?
Menopause is reached when at least 12 months have passed since a woman’s last menstrual cycle. However, menopause is not just a single turning point hat can be neatly marked off on a calendar. The process of a woman’s reproductive cycles coming to a close is a gradual transition that take years to complete over three distinct stages:
  • Perimenopause — In this first stage, hormonal production of estrogen, progesterone and other reproductive begins to shift and symptoms first appear and may become frequent and severe. Perimenopause can start as early as age 35, but for most women, usually begins in the mid-to-late 40s. Menstrual cycles continue but may become irregular.
  • Menopause —This culminating stage is confirmed by the cessation (stopping) of monthly periods for at least 12 months. Hot flashes and other symptoms continue if underlying hormonal imbalances are not addressed. The average age for menopause is 52.
  • Post-menopause —In this “after menopause stage,” a women’s hormones establish new patterns now that they’re no longer needed to support reproduction. Women entering post-menopause with hormonal imbalances often see their menopause symptoms persist — even years after they have stopped menstruating.
Beneath these simplified definitions, there’s a lot going on in a woman’s body, of course. During each of these stages, hormonal imbalances can trigger a range of symptoms, from hot flashes and night sweats to fatigue, low libido and more.
Symptoms and causes of menopause No two women will experience the menopause transition in the exact same way, and this no more true than when it comes to their symptoms. Some women sail through without so much as a single hot flash, while other women struggle with hormonal symptoms from the vey beginning of perimenopause.

For most women, menopause is an age-related event, but for other women, it can be the result of a hysterectomy or other intervention. The cause of your menopause can also influence your symptoms.

What are the signs and symptoms of menopause? It can be difficult to predict exactly what you might expect from menopause, but understanding which changes in your body may be related to this time of change is an important first step in figuring out what your body needs for support.

. If you experience one or more of the following symptoms, consider these your signposts that you have entered the menopause transition and your hormones are sending you an SOS that they could use some extra help staying in balance.

Irregular periods
Changes in your period are often the first signal that your sex hormones are beginning to shift in perimenopause. The most important question to answer about your period is, “is it irregular for you?” in terms of the length of your cycle or heaviness of your period.

Hot flashes and night sweats
Research suggests that decreased estrogen levels cause your body’s thermostat (hypothalamus) to become more sensitive to slight changes in body temperature, resulting in hot flashes and night sweats. Hot flashes can strike once a day, or up to 20 times or more, causing intense flashes of heat along with increased heart rate, dizziness, headache and even claustrophobia or the feeling of being trapped. They can be debilitating, especially when they occur and night and cause sleeplessness.

Sleep difficulties
You may toss and turn restlessly as you try to sleep, or wake up regularly in the middle of the night. Insomnia in menopause is often caused by a progesterone deficiency in perimenopause or menopause.

Weight gain
Changes to your weight or the shape of your body are another noticeable symptom. Shifting hormones tell your body to store fat in the abdominal area, creating a “meno belly,” even if you’ve never had a weight problem or extra belly fat before. Weight gain in perimenopause is difficult to lose even with diet and exercise.

Fatigue/loss of energy
Not getting enough sleep may make you feel tired, but exhaustion or crashing fatigue can occur even when you get a lot of rest, leaving you feeling physically and emotionally drained.

Forgetfulness or fuzzy thinking
One of the most alarming symptoms for many women is memory changes or fuzzy thinking — and it’s extremely common. This can also be a sign of an imbalance of estrogen and progesterone.

Thinning hair or hair loss
Many women start to notice clumps of hair in their shower drains during menopause or perimenopause. Imbalances between estrogen and testosterone can cause thinning hair.

Vaginal dryness
It can be a difficult symptom to discuss, but 50% of women in perimenopause and menopause experience vaginal changes, with dryness, itching and pain that affect their sex lives, activities and even the clothes they wear. Decreased estrogen can cause thinning of vaginal tissue, disrupting natural vaginal lubrication.

Low libido
While vaginal dryness can contribute to low libido, a drop in progesterone or a testosterone deficiency by itself can also leave you without a sex drive.

Dry and wrinkled skin and/or adult acne
When hormones shift out of balance, you can see it in the mirror in the form of dry and wrinkled skin, which can be related to lowered estrogen; or hormonal acne, which can be triggered by an imbalance of estrogen and testosterone.

Joint discomfort /stiffness
Joint pain or stiffness in the back, knees or hips is an unexpected symptom that may be caused by fluctuating estrogen levels. Hard to believe but true!

Food cravings
If you’ve always had food cravings with PMS, you may notice these urges to overeat are getting worse as you enter perimenopause and menopause. This can be due to your body’s increased needs for valuable micronutrients, or to the “crash cycle” pattern of fatigue/carbohydrates/fatigue with hormonal imbalance that so many of us fall into.

Digestive discomfort
Embarrassing and uncomfortable gas, diarrhea, constipation and other symptoms of digestive distress can all increase in perimenopause and menopause. And again, it’s due to pesky hormonal imbalance.

Anxiety and/or sadness
Perimenopause can raise your stress level, and can create hormonal imbalances that affect mood and emotional health. Stress hormones directly affect the production and balance of other hormones.

Irritability and/or moodiness
Feeling angry all the time and snapping at your friends and family doesn’t feel good — for you or them. Outbursts and mood swings are some of the first signs many women notice in perimenopause.

PMS-like symptoms
You may think stronger cramps, bloating, breast tenderness, headaches or mood swings are due to worsening PMS, but as symptoms get more frequent or severe, it’s often a sign of perimenopause.

What are the Causes of menopause?
Natural menopause
Menopause is caused by a change in the balance of the body’s sex hormones, which naturally and normally occurs as you get older. It happens when your ovaries stop producing as much of the hormone oestrogen and no longer release an egg each month.

Surgical menopause
Surgical menopause occurs after an oophorectomy, a surgery that removes the ovaries. The ovaries are the main source of estrogen production in the female body. Without time to transition, hormonal imbalances are often severe and may benefit from bioidentical hormonal treatment.

Premature or early menopause
Some women may go into menopause at an earlier age (late 30s or early 40s). In many cases there’s no clear cause. However, other causes of early menopause may be related to certain medical treatments, including breast cancer treatments, chemotherapy or radiotherapy, or it can be brought on by an underlying condition, such as Down’s syndrome or Addison’s disease.

How will I know if I am in menopause?
Menopause itself is a clear milestone, but that year of watching and waiting month after month to understand if “this is it!” can be confounding, especially for women may be experiencing irregular periods as a symptom of hormonal imbalance during perimenopause. They may go a few months without a period, or their period is spotty and light. It might feel like menopause is imminent, but then their menstrual cycle returns and the countdown is off.

There’s really no single moment to confirm that you’re entering menopause (and whether that first month of a missed period is actually part of menopause or just an irregular cycle). Instead, most women experience a gradual transition through perimenopause and eventually their period stops.

What is the normal menopause age?
The average age for women to enter menopause is 52, though it may occur up to two years earlier for Black and Latina women. More research is needed to understand menopause onset for women of color, but these general guidelines have been found to hold true.

Perimenopause can last anywhere from a few months to several years. Many women begin to notice significant perimenopausal symptoms at some point after their mid-40s. Some women skip perimenopause and enter menopause suddenly without warning. Still other women may experience recognizable symptoms of perimenopause beginning in their mid-30s.

What is premature menopause?
When you’re still in your early 40s and your periods stop — and don’t come back — you may find yourself in early menopause.

Early menopause occurs between the ages of 40 and 45 when a woman experiences menopausal symptoms and then goes a full 12 months without a period. About 5 percent of women undergo menopause between the ages of 40 and 45.

Many women at this age feel too young for menopause and the idea of losing their reproductive ability can be a real jolt. Even though this change may be hard to accept at first, once you understand what’s going on, you can take natural steps to feel good and support your overall health.

About 1 percent of women begin menopause before the age of 40, which is called premature menopause or primary ovarian insufficiency. Women in their 30s who enter menopause naturally may have an underlying hormonal issue and should discuss appropriate testing with their doctors.

Treatments for perimenopause and menopause
Conventional medicine tends to treat menopause as if it’s a disease. The basic argument is that during menopause the ovaries stop producing estrogen and symptoms arise, so replacing that estrogen with a prescription version will therefore quell your symptoms.

While this might be the right choice for some women, “treating” menopause with hormone replacement ignores the innate wisdom of your body and medicalizes a normal physiological process that women have experienced for centuries.

What is hormone therapy?
Synthetic hormone replacement therapy (HRT) was once the gold standard for conventional treatment of women’s menopause symptoms — until we learned the dire consequences of this approach. In 2004, the large-scale Women’s Health Initiative (WHI) revealed that synthetic HRT put women at serious risk of breast cancer, stroke and other life-threatening disorders. The study was a bombshell because, at the time, more than 10 million women were being prescribed some form of synthetic HRT, most commonly during menopause.

The forms of synthetic HRT studied in the WHI included medications such as conjugated equine estrogen (Premarin) and synthetic progestins. Many conventional doctors backed off prescribing these drugs. But guess what? Thanks to the powerful driving force of Big Pharma, synthetic HRT has been creeping back as a standard treatment offered to women — with the same risks!

The Lancet recently studied current offerings of synthetic HRT. This was good science that showed that 15 years later, nothing has changed!

Here is what I tell my patients: these synthetic hormones have no place in your body. Women have so many other ways to effectively rebalance your hormones. It’s always worth exploring these options.

What are non-hormonal therapies for menopause?

I understand how disruptive menopause symptoms can be to your life — hot flashes, night sweats, weight gain, irritability, irregular periods, and worse — feeling exhausted most of the time. The good news is that when a woman needs help for her symptoms, targeted herbal remedies — or phytotherapy — can make a huge difference for menopause symptom relief.


New research is constantly showing us how plant molecules act to balance hormones naturally, just as they have for thousands of years.

One reason phytotherapy is so effective is that certain herbs (known as phytocrines) share important features with natural hormones, thus enabling them to increase the body’s natural ability to make and use hormones and provide symptom relief.
Because phytotherapy works with your body, it can powerfully alleviate your worst symptoms, but without the side effects. If we’re used to medicines taking immediate effect, just keep in mind that the healing qualities of phytotherapy are usually more subtle — but they are working!

Evidence for phytotherapy is strong. Naturopathic physician Tori Hudson reminds us that using herbs for menopause isn’t a new concept in her article on Menopause Botanicals. As Dr. Hudson explains, “Many herbs have been used traditionally by herbalists and women for decades, and in some cases centuries, to address menopausal symptoms. Although many of the traditionally used plants lack clinical studies for this purpose, the empirical evidence and tradition [are] strong.”
Leading healthcare
Providers
Photo of Sheila – Sheila Jiwan is a Pharmacist and Fellow in Anti-Aging and Functional Medicine and provides women and men optimized hormone therapy to improve the quality of their lives. She works in conjunction with leading specialists in the field of hormone testing, Naturopathy and Customised Compounding of Bio-Identical Hormone Therapy.

What our customer are saying

Check out our latest article

ZRT link on evidence based testing - ZRT Laboratory | Innovative Lab Testing Made Simple

Lorem ipsum dolor sit amet, consectetur adipiscing elit. Ut elit tellus, luctus nec ullamcorper mattis, pulvinar dapibus leo.

PMS/PCOS/Endometriosis

Lorem ipsum dolor sit amet, consectetur adipiscing elit. Ut elit tellus, luctus nec ullamcorper mattis, pulvinar dapibus leo.

Progesterone

Lorem ipsum dolor sit amet, consectetur adipiscing elit. Ut elit tellus, luctus nec ullamcorper mattis, pulvinar dapibus leo.